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KMID : 0379520210370020183
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한국독성학회지
2021 Volume.37 No. 2 p.183 ~ p.195
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Phytochemical and toxicological evaluations of Prosopis africana (GUILL. and PERR.) extract on albino wistar rats
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Obode Okukwe Christa
Adebayo Abiodun Humphrey
Li Chunyang
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Abstract
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In this study, we investigated the phytochemical and toxicological impacts of the ethanol leaf extract of Prosopis africana in albino rats. Preliminary phytochemical analysis was done using established methods. Acute and 28-day sub-chronic toxicity evaluations of the extract were carried out in wistar rats. Five groups made up of 8 rats per group were used and treated with 500, 1000, 1500 and 2000 mg/kg b.wt. respectively; while the control group received 1 ml of 10% Tween-20 solution. Phytochemicals detected include tannins, saponins, flavonoids, alkaloids, anthocyanin, quinones, terpenoids and steroids. There were no signs of toxicity in the acute toxicity study neither was any death recorded. Weight loss and death were recorded after 18 days of treatment in groups treated with 1500 and 2000 mg/kg b.wt. No significant alteration of haematological parameters was observed, however increased WBC count was recorded. Liver and kidney function parameters were significantly (p?
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KEYWORD
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Medicinal plants, Prosopis africana, Toxicity, Phytochemicals, Wistar rats
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